Sept. 6, 2022

Revolutionizing organ preservation and transplantation by mimicking antifreeze proteins of Arctic fish

Revolutionizing organ preservation and transplantation by mimicking antifreeze proteins of Arctic fish

Xiaoxi Wei, Ph.D (CEO) and Mark Kline, Ph.D. (CTO) are the cofounders of X-Therma, a biotechnology startup developing a breakthrough technology for regenerative medicine and organ preservation. In this episode of lab to startup, we talk about the...


Xiaoxi Wei, Ph.D (CEO) and Mark Kline, Ph.D. (CTO) are the cofounders of X-Therma, a biotechnology startup developing a breakthrough technology for regenerative medicine and organ preservation.

In this episode of lab to startup, we talk about the challenges around  organ preservation and transplantation; and how a technology they developed at Lawrence Berkeley National laboratory is being used to increase the life of organs to up to a week.We will talk about the inspiration to launch the startup, unique success around raising non-dilutive funding; creating a culture, and the importance of freedom to take decisions not driven by investors; Last but not the least, we will also get into their personal life briefly, as Xaoxi and Mark are unique co-founders on that front.

Show notes
https://x-therma.com
- Peptoid research originally developed for a DARPA project formed the basis for the underlying technology
- Biomimicking chemistry in nature (fishes) to overcome freezing problems
- Solid organ transplant still very inefficient due to limited amount of time to transport and transplant an organ
- Product evolution
- Determining the first product to develop, timing and timelines
- SBIR grants and VC funding
- Building the startup as an outsider (non-cryobiology experts) & role of KOLs
- Turning down term sheets
- The power of freedom while building startups by taking in the right money
- Challenges in the organ preservation space
- X-Therma assisting cell and gene therapy.
- FDA Breakthrough device status
- Culture and lessons learnt from hiring
- Being partners at work and at home
- Careers: https://x-therma.com/join-us/